Investigating Preventive Effect of Vitamin D and N-acetylcysteine Against Kidney Injury in Rats Versus the Promotive Effect of Paraquat

Background: Paraquat (PQ) is one of the most important herbicides used in agriculture. Objectives: This study was conducted to compare preventive effect vitamin D (Vit D) and N-acetylcysteine (NAC) against kidney injury rats versus promotive PQ. Methods: In this study, were divided into six groups. The control group (group 1) received normal saline, Vit 2) intraperitoneal (IP) injections of+Vit (2 μg/kg), NAC 3) (6.25 mg/kg, IP), PQ 4) (5 mg/kg/d, PQ+Vit 5) mg/kg/d+2 μg/kg/d, IP) PQ+NAC 6) mg/kg/d+6.25 IP). animals treated for 7 consecutive days as a sub-chronic exposure. After collection urea serum creatinine, biomarkers oxidative stress histopathology investigated. Results: increased lipid peroxidation (LPO), urea, but it significantly decreased total antioxidant capacity (TAC) thiol groups with NAC, observed that LPO, creatinine decrease compared group, TAC, groups, levels tissue. Conclusion: obtained findings revealed both compound able reduce tissue damage caused by toxicity kidney.